Israel's military pounded targets in the Gaza Strip on Tuesday after Prime Minister Benjamin Netanyahu said his country should prepare for a long conflict in the Palestinian enclave, squashing any hopes of a swift end to 22 days of fighting.

Gaza residents reported heavy Israeli bombing in Gaza City.

Israeli aircraft fired a missile at the house of Hamas Gaza leader Ismail Haniyeh and flattened it before dawn, causing damage but no casualties, Gaza's interior ministry said.

An Israeli military spokeswoman said 70 targets were struck in Gaza through the night. At least 30 people were killed in the assaults from air, land and sea, residents said, after a night of the most widespread attacks so far in the coastal enclave.

"My house is not dearer than any of the houses of our people," Haniyeh was quoted as saying on a Hamas website. "The destruction of stones will not break our will and we will continue our resistance until we gain freedom."

The Israeli military said five soldiers were killed in a battle with militants who crossed into Israel via a tunnel near the community of Nahal Oz, close to the Gaza border.